Experimental observations of the effects of short-pulsed lasers on tattoos were first reported in the late 1960s by Leon Goldman and others.[22][23][24] In 1979 an argon laser was used for tattoo removal in 28 patients, with limited success. In 1978 a carbon dioxide laser was also used, but because it targeted water, a chromophore present in all cells, this type of laser generally caused scarring after treatments.[25][3][26][2]
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